Publications

 

EASL 2019 late-breaker poster: Icosabutate a structurally engineered fatty acid, icosabutate, rapidly normalises elevated plasma ALT and gamma-glutamyl transferase (GGT) concentrations in a study population at high risk of NAFLD/NASH

EASL 2019 poster: Icosabutate induces a potent reduction in hepatic oxidative stress in multiple rodent models of metabolic stress and fibrosing NASH

AASLD 2018 poster: Icosabutate, a novel structurally engineered fatty-acid, exhibits potent anti-inflammatory and anti-fibrotic effects in a dietary mouse model resembling progressive human NASH

AASLD 2018 poster: A liver-targeted structurally engineered fatty acid, icosabutate, potently reduces hepatic pro-fibrotic gene expression and improves glycemic control in an obese diet-induced mouse model of NASH

EASL 2018 late-breaker poster: A structurally engineered fatty acid, icosabutate, displays optimised absorption, distribution and metabolism properties for targeting hepatic inflammation and normalises elevated liver enzymes in dyslipidemic patients.

Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial.

Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia.

“We believe icosabutate has the potential to impact the lives of millions of NASH patients globally” Rob de Ree

Chief Executive Officer, NorthSea Therapeutics

Voor meer informatie:

info@northseatherapeutics.com

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